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admin
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Joined: 08 Dec 2003
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 Posted: Mon Jul 20, 2009 10:09 am Post subject: Question 4 |
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javier.cab2947
Joined: 11 Jan 2009
Posts: 2
Posted: 09 Feb 2009 12:15 pm Post subject: Questions 4 and 5
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| Quote: | The main fibronectin receptors are integrins (VLA-4, I think), and recognize fibronectin on the OUTER surface of the lipid bilayer.
Some transmembrane receptors can bind the ligand in the transmembrane domain, but NOT receptors for fibronectin.
Why is choice A wrong? |
jellywing_2058
Joined: 04 May 2009
Posts: 68
Posted: 27 May 2009 08:22 am Post subject: #4
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| Quote: | Fibronectin is on the outer surface of the cell in the extracellular fluid (Campbell Reese p.119), however the text says “This role appears to be filled by a transmembrane fibronectin receptor and other proteins.” (P3 L9)
The question asks where the receptor is located: IN the bilayer (B) since it is a transmembrane receptor. Answer choice A. Cannot be the best answer since it is incomplete. The transmembrane receptor will indeed have a small portion in the extracellular surface but, by nature of the word transmembrane, this important protein goes through the membrane to the intracellular surface as well. |
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quadalpha
Joined: 21 Feb 2010
Posts: 65
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| Posted: Wed Mar 10, 2010 2:35 pm Post subject: |
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| B can imply it is entirely within the membrane. What is the reasoning against D? Something that attaches fibronectin to actin should be next to actin, right? |
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admin
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| Posted: Wed Jun 09, 2010 3:54 pm Post subject: |
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| This question has been modified for clarification |
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